Silent systemic inflammation is the often hidden symptoms of our biologies ‘emergency services’ alarms going off across the body. While inflammation is important to a healthy and natural immune response, inflammation which persists and goes unchecked can continue to spread throughout the body causing harm.

Inflammation can be caused by a number of internal and external factors including poor diet, physical inactivity, obesity, disturbed sleep, chronic stress, overexertion, poor gut microbiome, smoking, air pollution and more. 

No, not all inflammation is bad. In fact, having a healthy inflammatory response is essential to a properly functioning immune system. The issue arises when inflammation persists unchecked and changes from a short-term, healthy inflammatory response to long-term, silent, systemic inflammation. 

Acute inflammation is a natural and healthy immune response to damage or infection. For example, you cut your finger and it becomes a bit red, swollen, hot and possibly painful - all signs of an inflammatory response. However, these symptoms fade as the wound heals and your finger returns to normal. 

Chronic inflammation is persistent inflammation which does not turn off and can result in further complications and damage. For example, consistent, long-term joint inflammation can continually result in cartilage tissue damage, further driving inflammation in a harmful cycle.

When it comes to inflammation, it is all down to cytokines within our bodies. Cytokines are small proteins involved in cell signalling that turn on and off the inflammatory response, balancing inflammation for a healthy immune system. 

Cytokines are small proteins involved in cell signalling; essential to the body's immune response and natural balance. Cytokines are the coordinators of inflammation and our immune system. 

Cytokines allow the many different systems within our body to communicate and are essential to its natural balance. Pro-inflammatory cytokines signal to our immune system that there is damage or injury, and should therefore increase blood flow (swelling and redness), directing white blood cells to the location for repair, as well as heat to kill the infection. Anti-inflammatory cytokines decrease the immune response, preventing damage from excessive systemic inflammation. 

Inflammation is important as it is our natural immune response. It signals an alarm that something is wrong. When inflammation persists beyond a short-term response, however, it becomes damaging to healthy tissues and cells while reducing the sensitivity to future signals. 

Silent systemic inflammation can lead to a harmful cycle once out of hand. Inflammation is our body's ‘alarm signal’ to respond to damage or infection, but if this signal persists without end, the body becomes resistant to the signal while the symptoms of inflammation - swelling, redness, heat and pain will continue resulting in damage which could eventually lead to loss of function. 

Inflammation can be found across every system within the body.

• Cardiovascular - myocarditis, pericarditis and endocarditis are inflammatory cardiovascular conditions which can result from cholesterol buildup, infections, stress and lead to further cardiovascular risk. 
• Digestive - often referred to as inflammatory bowel disease (IBD), this includes Crohn’s disease and ulcerative colitis, which is characterised by swelling, pain, diarrhea and bleeding.
• Metabolic - Diabetes, fatty liver disease, fatigue, chronic fatigue syndrome, inability to sleep, poor sleep, energy crashes.
• Skin - Common inflammatory conditions include eczema and psoriasis resulting in redness, swelling, pain and itching. 
• Respiratory - bronchitis is inflammation of the bronchial tube while pneumonia is acute inflammation of the lung tissue itself. Chronic lung inflammation includes conditions like asthma and COPD.
• Nervous - neuroinflammation is inflammation of the brain or spinal cord, involves glial cells releasing cytokines and inflammatory mediators, which can damage neurons and inhibit function and cause cognitive decline. 
• Muscular - Myositis is inflammation of the muscles resulting in muscle pain, weakness and fatigue. 
• Skeletal - Osteitis is inflammation of the bone and arthritis resulting in pain, swelling, heat and tenderness.
• Endocrine - endocrine inflammation can arise from autoimmune disorders, infections, or hormonal imbalance like insulin resistance which can lead to further complications like obesity or inflammatory bowel disease.
• Lymphatic - lymphadenitis is inflammation within the lymphnodes which can be caused by bacteria or viral infections and result in swollen, tender nodes, fever, red streaks on the skin. 
• Urinary - inflammation of the urinary system, also known as urinary tract infections (UTIs), commonly referred to as cystitis, can be painful with frequent burning urination. 
• Reproductive - the most common condition Pelvic Inflammatory Disease (PID) can result in severe pain and infertility, as well as other serious complications.

There are many things we can do to combat inflammation including having a healthy, well balanced diet, keeping physically active, having a quality sleep routine, reducing stress, allowing time for recovery when needed and focusing on healthy digestion and gut microbiome.

The landscape of nutrition has long been changing. We are living longer than ever, with more demanding lives than ever, but our food is not nearly as nutritious as it used to be. Food now is produced for convenience, long journeys and shelf lives, over nutritious value. This can lead to deficiencies within our diet which can further drive inflammation and health complications.

At One was created to offer the highest quality health formulation which actually focuses on inflammation, the root cause of disease, while supporting our natural 24 hour circadian cycle and offering the best dosages and nutrient forms required to reduce inflammation to feel your best everyday. 

The Morning Start -

Apple Cider Vinegar with The Mother (Malus pumila), Chlorella Microalgae, Magnesium Citrate, Coconut Medium Chain Triglyceride Powder, L-Glutathione, Vitamin C Calcium Ascorbate, Natural Flavourings, Coenzyme Q10, Magnesium Taurate, L-Choline, Jerusalem Artichoke Soluble Fibre, Turmeric Root Extract, 1-3 / 1-6 Yeast Beta Glucans, L-Carnitine L-Tartrate, Vitamin E Natural D-Alpha-Tocopheryl, Zinc Citrate, Vitamin K2 Menaquinone-7 (MK7), Sodium Selenite, Stevia Extract (Stevia rebaudiana), Manganese Citrate, Piperine Black Pepper Extract, Molybdenum Bisglycinate, Copper Gluconate, Vitamin B2 Riboflavin, Vitamin B1 Thiamine HCl, Vitamin D3 Cholecalciferol, Vitamin B12 Methylcobalamin, Vitamin B9 L-5-Methyltetrahydrofolate Calcium MTHF, Chromium Picolinate, Cayenne Pepper Fruit Whole Extract, Vitamin B7 D-Biotin.

The Evening Restore -

Chicory Root Soluble Fibre, Chlorella Microalgae, Magnesium Citrate, Magnesium Bisglycinate, Coconut Medium Chain Triglyceride Powder, L-Glycine, Chamomile Flower Extract 5:1 (Matricaria recutita), L-Glutamine, Green Tea Extract Natural L-Theanine (Camellia sinensis), Monk Fruit, Natural Flavourings, Trans Resveratrol Japanese Knotweed Root Extract, White Mulberry Extract 5:1 (Morus alba l.), Cinnamon Ceylon Bark Extract 10:1 (Cinnamomum zeylanicum), Disodium Uridine-5-Monophosphate, Ashwagandha Root Extract (Withania somnifera), Pomegranate Peel Extract 5:1 (Punica granatum), Cacao, Vitamin B3 Nicotinamide, Astaxanthin, Vitamin B5 Calcium Pantothenate, Stevia Extract (Stevia rebaudiana), Vitamin B6 Pyridoxal 5-Phosphate Monohydrate (P5P), Vitamin D3 Cholecalciferol.

At One is suitable for anyone over the age of 18. As with all health supplements, we recommend discussing with your GP before taking anything. 

At One is not currently formulated for children and is recommended for individuals over the age of 18. 

The Morning Start is best first thing in the morning for all day energy. You can have the Morning Start in cold or warm water, or mix with your favourite juice or smoothie.

The Evening Restore is best about an hour before bed to help you relax for a restful night sleep. You can have the Evening Restore in cold or warm water, or we recommend mixing with milk or your favourite milk alternative for the perfect cozy slumber drink. 

Within your first box of the Morning Start, you will notice significantly more energy throughout the day without a crash, improved metabolism for energy generation, mental focus and reduced brain fog, healthier hair, skin and nails as well as a strengthened immune system to help fend off infections.

Within your first box of the Evening Restore, you will notice falling into a much more restorative sleep routine, helping to relax and calm the mind before sleep, while also promoting muscle recovery, supporting immune system recovery and function, as well as balancing your hormones to help you feel your best come morning. 

At One are not only the most inflammation focused formulations available, they also completely support the body's natural circadian rhythm over 24 hours to deliver the most noticeable benefits. 

The Morning Start gets you fired on all cylinders supporting metabolism, mental performance, immune system function, healthy hair and nails and of course all day energy without a crash. 

The Evening Restore is the peak relaxation night cap supporting a peaceful mind, muscle recovery, immune system function and hormone harmony, all wrapped up in the most restful night sleep.

The At One formulations The Morning Start and The Evening Restore absolutely work better together. They are the perfect compliment, offering significant nutrient synergy across the two formulations. Our bodies have very different needs when it comes to supporting our physiology whether it's waking up for an active day or going to sleep for a restorative rest, At One fully supports your natural circadian rhythm over all 24 hours in a day. 

At One does not contain allergens. However, as with all health supplements it is recommended to discuss with your GP before taking anything. 

Both the Morning Start and Evening Restore are 100% suitable for vegans.

Both the Morning Start and Evening Restore are 100% gluten-free.

Both the Morning Start and Evening Restore are 100% dairy-free.

Most people notice significant benefits within their first box. As with all health supplements, consistency is key as everyone's physiology is different and maybe respond uniquely. 

Consistency and building a routine is key to good health, so the greatest benefits come from taking At One everyday.

As with all health supplements, we recommend discussing with your GP before taking if pregnant or breastfeeding. There are no issues taking At One when trying to conceive.

As with all health supplements, we recommend discussing with your GP before taking if prescribed medication.

All ingredients within At One formulations are completely natural, backed by science and highly researched as essential for a healthy physiology. However, everyone is different, therefore, if any side effects are noticed to stop taking and discuss with your GP.

Yes, no problem. Our Daily Ritual is a good way to get started. But you may find our flexible subscription cheaper and more convenient. You can stay on it if At One works for you or amend or cancel anytime.

When you start a subscription, your first payment will be taken straight away. After that, any subscription payments will be taken from your card on the same date every month.

We deliver to all counties in Ireland and Northern Ireland. Our deliveries to Ireland and Northern Ireland are shipped with DPD. You will receive a text message or email from DPD on the day of your delivery with an estimated time of delivery of your order. DPD offer a Parcel Wizard service that allows you to choose a day that suits to have your parcel delivered and you can also advise where you want your parcel delivered. In order to use this service you need to register at www.dpdparcelwizard.ie

Delivery to the United Kingdom**: We are unable to ship to the UK at this time. We are shipping to Northern Ireland as normal.

Ireland & Northern Ireland

Orders usually take between 2-4 working days to be delivered in Ireland and Northern Ireland with the exception of Bank Holidays, Black Friday weekend and during sale times where orders can take up to 7 working days to be dispatched. Orders are delivered by DPD.

Yes, our boxes are fully recyclable

We are unable to ship subscription products to the UK. We are shipping to Northern Ireland as normal. 

We can ship subscriptions to other countries, you will be charged shipping on each delivery the cost of which is dependent on the country to which it is being shipped.

We do however ship to most countries subject to standard shipping costs.

It’s really easy to make changes to your subscription through your online account. You can also email hello@feelatone.ie and we can sort it for you. 

Just remember you can make changes up to 48 hours before your delivery is due. After that, it’s too late to alter an order. 

Good to know: all our subscriptions give you the flexibility to pause your subscription. Or simply delay your monthly orders. This is handy if you’re going on holiday.

A flexible subscription can be cancelled anytime. 

All our subscriptions give you the flexibility to delay your monthly orders. This really helps if you’re going on holiday or heading to hospital for an op, for example.  

We accept all major credit and debit cards, excluding AMEX. Payments will be taken before your pack is sent to you. 

As soon as your payment has gone out, you’ll receive an email letting you know that your order is ready to be sent. Then another email will be sent once it’s on its way. 

At the moment you can’t make recurring payments by ApplePay or GooglePay.

Simply log in to your online account and go to manage my subscriptions. There, you can add or change the payment method. You can also contact us by email at hello@feelatone.com and we’ll do it for you.

You can view our terms and conditions here